Shahavi V M, Desai S K
Prin.KM Kundnani College of Pharmacy, Colaba, Mumbai-400005, India.
Fitoterapia. 2008 Feb;79(2):82-5. doi: 10.1016/j.fitote.2007.06.014. Epub 2007 Aug 11.
Methanolic extract of Butea monosperma flowers (MEBM) was studied for anti-inflammatory activity against carrageenin induced paw edema and cotton pellet granuloma in albino rats. In carrageenin induced paw edema, MEBM at oral doses of 600 mg/kg and 800 mg/kg, dose-dependently inhibited the paw edema. In cotton pellet induced granuloma, MEBM at the same doses was found to significantly inhibit granuloma tissue formation, including significant reduction in levels of serum lysosomal enzymes (SGOT, SGPT and ALP) and lipid peroxides as compared to control.
对紫铆花的甲醇提取物(MEBM)针对角叉菜胶诱导的白化大鼠爪肿胀和棉球肉芽肿的抗炎活性进行了研究。在角叉菜胶诱导的爪肿胀实验中,口服剂量为600mg/kg和800mg/kg的MEBM剂量依赖性地抑制了爪肿胀。在棉球诱导的肉芽肿实验中,发现相同剂量的MEBM能显著抑制肉芽肿组织形成,与对照组相比,血清溶酶体酶(SGOT、SGPT和ALP)水平及脂质过氧化物显著降低。