孕期使用抗抑郁药物：一项多中心研究。
Use of antidepressant medications during pregnancy: a multisite study.
作者信息
Andrade Susan E, Raebel Marsha A, Brown Jeffrey, Lane Kimberly, Livingston James, Boudreau Denise, Rolnick Sharon J, Roblin Douglas, Smith David H, Willy Mary E, Staffa Judy A, Platt Richard
机构信息
Meyers Primary Care Institute, Worcester, MA 01605, USA.
出版信息
Am J Obstet Gynecol. 2008 Feb;198(2):194.e1-5. doi: 10.1016/j.ajog.2007.07.036. Epub 2007 Oct 1.
OBJECTIVE
This study was undertaken to provide information on the prevalence of use of antidepressant drugs among pregnant women in the United States.
STUDY DESIGN
A retrospective study was conducted using the automated databases of 7 health plans. Women who delivered an infant in a hospital were identified. Antidepressant drug use was evaluated assuming a gestational duration of 270 days.
RESULTS
Among the 118,935 deliveries occurring from 2001-2005, 6.6% of women were dispensed an antidepressant during pregnancy. Antidepressant drug use increased from 2.0% in 1996 to 7.6% of deliveries in 2004 and 2005. Selective serotonin reuptake inhibitor use increased from 1.5% in 1996 to 6.4% in 2004 and 6.2% in 2005.
CONCLUSION
Our finding that nearly 8% of pregnant women were prescribed antidepressants drugs during the years 2004 and 2005 highlights the importance of understanding the effects of these medications on the developing fetus and on the pregnant woman.
目的
本研究旨在提供美国孕妇中抗抑郁药物使用 prevalence 的信息。
研究设计
使用7个健康计划的自动化数据库进行回顾性研究。确定在医院分娩婴儿的妇女。假设妊娠期为270天，对抗抑郁药物的使用进行评估。
结果
在2001年至2005年发生的118,935例分娩中，6.6%的妇女在孕期被配给了抗抑郁药物。抗抑郁药物的使用从1996年的2.0%增加到2004年和2005年分娩的7.6%。选择性5-羟色胺再摄取抑制剂的使用从1996年的1.5%增加到2004年的6.4%和2005年的6.2%。
结论
我们的发现表明，在2004年和2005年期间，近8%的孕妇被开了抗抑郁药物，这凸显了了解这些药物对发育中的胎儿和孕妇影响的重要性。 （注：原文中“prevalence”未准确翻译，可能是“流行率”之类更合适的表述，但按要求未做调整）
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