急性髓系白血病的分子特征及其对治疗的影响。
Molecular characterization of acute myeloid leukemia and its impact on treatment.
作者信息
Frankfurt Olga, Licht Jonathan D, Tallman Martin S
机构信息
Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois 60611, USA.
出版信息
Curr Opin Oncol. 2007 Nov;19(6):635-49. doi: 10.1097/CCO.0b013e3282f10e55.
PURPOSE OF REVIEW
Molecular aberrations are playing an ever increasing role in guiding classification, prognosis, and therapeutic strategies in patients with acute myeloid leukemia. This review outlines recent strides in our understanding of the molecular characteristics of acute myeloid leukemia.
RECENT FINDINGS
We highlight the novel concept of preferential co-expression of certain mutations, summarize recent data on the clinically relevant prognostic role of known and novel molecular aberrations, and emphasize the emerging role of gene expression profiling and minimal residual disease monitoring.
SUMMARY
We review the molecular heterogeneity within already established categories of acute myeloid leukemia and discuss how these data may translate into prognostic, molecular-based therapy stratification to improve patient outcome.
综述目的
分子异常在指导急性髓系白血病患者的分类、预后评估及治疗策略方面正发挥着越来越重要的作用。本综述概述了我们对急性髓系白血病分子特征理解的最新进展。
最新发现
我们强调了某些突变优先共表达的新概念，总结了关于已知和新型分子异常的临床相关预后作用的最新数据，并强调了基因表达谱分析和微小残留病监测的新兴作用。
总结
我们回顾了急性髓系白血病已确立类别中的分子异质性，并讨论了这些数据如何转化为基于分子的预后治疗分层以改善患者预后。
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