Wang Qun, Zhang Na, Hu Xianwen, Yang Jianhong, Du Yumin
Department of Environmental Science, Wuhan University, Wuhan 430072, People's Republic of China.
J Biomed Mater Res A. 2008 Jun 15;85(4):881-7. doi: 10.1002/jbm.a.31544.
Fibers of chitosan and polyethylene glycol (PEG), with salicylic acid as model drug incorporated in different concentrations, were obtained by spinning their solution through a viscose-type spinneret into a coagulating bath containing aqueous tripolyphosphate and ethanol. Chemical, morphological, and mechanical properties characterization were carried out, as well as the studies of the factors that influence the drug releasing from chitosan/PEG fibers. These factors included the component ratio of chitosan and PEG, the loaded amount of salicylic acid, the pH and the ionic strength of the release solution and others. The diameter of the fibers is around 15 +/- 3 microm. The best values of the tensile strength at 12.86 cN/tex and breaking elongation at 21.13% of blend fibers were obtained when the PEG content was 8 and 5 wt %, respectively; the water-retention value of blend fibers increased as the composition of PEG was raised. The results of controlled release tests showed that the amount of salicylic acid released increased with an increase in the proportion of PEG present in the fiber. Moreover, the release rate of drug decreased as the amount of drug loaded in the fiber increased, but the cumulative release amount is increasing. The chitosan/PEG fibers were also sensitive to pH and ionic strength. The release rate was being accelerated by a lower pH and a higher ionic strength, respectively. All the results indicated that the chitosan/PEG fiber was potentially useful in drug delivery systems.
以不同浓度将水杨酸作为模型药物，通过将壳聚糖和聚乙二醇（PEG）的溶液经粘胶型喷丝头纺丝到含有三聚磷酸盐水溶液和乙醇的凝固浴中，制备出了纤维。对其进行了化学、形态和力学性能表征，以及对影响壳聚糖/PEG纤维药物释放的因素进行了研究。这些因素包括壳聚糖与PEG的组分比例、水杨酸的负载量、释放溶液的pH值和离子强度等。纤维直径约为 $15 \pm 3$ 微米。当PEG含量分别为8 wt%和5 wt%时，共混纤维的拉伸强度最佳值为12.86 cN/tex，断裂伸长率为21.13%；共混纤维的保水值随着PEG组成的增加而提高。控释试验结果表明，水杨酸的释放量随着纤维中PEG比例的增加而增加。此外，药物释放速率随着纤维中药物负载量的增加而降低，但累积释放量在增加。壳聚糖/PEG纤维对pH值和离子强度也很敏感，较低的pH值和较高的离子强度分别会加速释放速率。所有结果表明，壳聚糖/PEG纤维在药物递送系统中具有潜在的应用价值。
