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从构象子到人类大脑:非线性动力学及其在生物医学中的应用概述

From conformons to human brains: an informal overview of nonlinear dynamics and its applications in biomedicine.

作者信息

Klonowski Wlodzimierz

机构信息

Institute of Biocybernetics and Biomedical Engineering Polish Academy of Sciences, Warsaw, Poland.

出版信息

Nonlinear Biomed Phys. 2007 Jul 5;1(1):5. doi: 10.1186/1753-4631-1-5.

Abstract

Methods of contemporary physics are increasingly important for biomedical research but, for a multitude of diverse reasons, most practitioners of biomedicine lack access to a comprehensive knowledge of these modern methodologies. This paper is an attempt to describe nonlinear dynamics and its methods in a way that could be read and understood by biomedical professionals who usually are not trained in advanced mathematics. After an overview of basic concepts and vocabulary of nonlinear dynamics, deterministic chaos, and fractals, application of nonlinear methods of biosignal analysis is discussed. In particular, five case studies are presented: 1. Monitoring the depth of anaesthesia and of sedation; 2. Bright Light Therapy and Seasonal Affective Disorder; 3. Analysis of posturographic signals; 4. Evoked EEG and photo-stimulation; 5. Influence of electromagnetic fields generated by cellular phones.

摘要

当代物理学方法在生物医学研究中日益重要,但由于多种不同原因,大多数生物医学从业者缺乏对这些现代方法的全面了解。本文试图以一种生物医学专业人员能够阅读和理解的方式来描述非线性动力学及其方法,这些专业人员通常未接受过高等数学训练。在概述了非线性动力学、确定性混沌和分形的基本概念及词汇后,讨论了生物信号分析非线性方法的应用。特别介绍了五个案例研究:1. 监测麻醉和镇静深度;2. 强光疗法与季节性情感障碍;3. 姿势描记信号分析;4. 诱发脑电图和光刺激;5. 手机产生的电磁场的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bac6/1997128/5f2ed8c2f448/1753-4631-1-5-1.jpg

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