通过沉默信息调节因子1（SIRT1）消除胰岛素抵抗
Silencing insulin resistance through SIRT1.
作者信息
Zabolotny Janice M, Kim Young-Bum
机构信息
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
出版信息
Cell Metab. 2007 Oct;6(4):247-9. doi: 10.1016/j.cmet.2007.09.004.
Insulin resistance is an important risk factor for the development of type 2 diabetes and the metabolic syndrome. A new study in this issue of Cell Metabolism (Sun et al., 2007) shows that SIRT1, a mammalian sirtuin homolog and histone deacetylase, can ameliorate insulin resistance by silencing expression of protein tyrosine phosphatase 1B, a major negative regulator of insulin action.
胰岛素抵抗是2型糖尿病和代谢综合征发生的重要危险因素。本期《细胞代谢》（Sun等人，2007年）的一项新研究表明，SIRT1（一种哺乳动物沉默调节蛋白同源物和组蛋白脱乙酰酶）可通过使胰岛素作用的主要负调节因子蛋白酪氨酸磷酸酶1B的表达沉默来改善胰岛素抵抗。
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