相关HLA匹配的脐血移植后发生的超急性移植物抗宿主病
Hyperacute graft-vs.-host disease after related HLA-identical umbilical cord blood transplantation.
作者信息
Kuskonmaz Baris, Gocer Safak, Ersoy-Ewans Sibel, Cetin Ozman Fatma, Cetin Mualla, Uckan Duygu
机构信息
Pediatric Hematology Unit, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
出版信息
Pediatr Transplant. 2007 Nov;11(7):818-20. doi: 10.1111/j.1399-3046.2007.00786.x.
haGVHD has been described following bone marrow and peripheral blood stem cell transplantation and in a single case who received unrelated HLA mismatched CB. An unusual case of haGVHD following HLA 6/6-matched sibling CBT in a child with AML is presented. The development of haGVHD in a fully matched CBT and without precipitating factors may suggest the role of still undefined and perhaps individual contributory factors.
已有报道称，在骨髓和外周血干细胞移植后以及在一例接受不相关HLA配型不合脐血的患者中发生了移植物抗宿主病（haGVHD）。本文报告了一例急性髓系白血病（AML）患儿在接受HLA 6/6全相合同胞脐血移植后发生haGVHD的不寻常病例。在完全匹配的脐血移植中且无诱发因素的情况下发生haGVHD，可能提示仍未明确且或许存在个体促成因素的作用。
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