Stecker Michael S, Johnson Matthew S, Ying Jun, McLennan Gordon, Agarwal David M, Namyslowski Jan, Ahmad Iftikhar, Shah Himanshu, Butty Sabah, Casciani Thomas
Department of Radiology, Division of Angiography and Interventional Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA.
J Vasc Interv Radiol. 2007 Oct;18(10):1232-9; quiz 1240. doi: 10.1016/j.jvir.2007.06.035.
Many patients undergo placement of tunneled cuffed central venous catheters (TCCVCs) for indications including administration of medical therapy and hemodialysis. They are removed when no longer needed or if there is a device complication. There is no consensus regarding the necessity of routine preremoval coagulation studies or platelet count, so this study was performed to determine if abnormal coagulation status affects the time to hemostasis (TH) after traction removal of TCCVCs.
Adult patients referred to our group for removal of a TCCVC placed via a jugular or subclavian route were considered candidates for inclusion. Blood was submitted for evaluation of prothrombin time (PT) and International Normalized Ratio (INR), activated partial thromboplastin time (aPTT), and platelet count. Catheters were removed with the traction technique, and presence of hemostasis was assessed at 5-minute intervals of manual compression.
Between November 19, 2001, and April 20, 2004, 179 subjects were enrolled and completed the study. There were 165 subjects in whom TH was within the first 5-minute interval and 14 in whom more than 5 minutes was required. Statistically significant factors associated with prolonged TH were primary diagnosis of end-stage renal disease (P = .005), use of antiplatelet agents (P = .03), and procedure performed by a "low-volume" operator (P = .002).
Routine preremoval evaluation of coagulation parameters is not necessary. Patients who are likely to have abnormal platelet function but not abnormal platelet number appear to be at risk for prolonged TH, but even in those cases, the THs are rarely more than 15 minutes.
许多患者因包括药物治疗和血液透析等适应证而接受带隧道带涤纶套中心静脉导管(TCCVC)置入。当不再需要或出现装置并发症时将其拔除。对于常规拔除前进行凝血研究或血小板计数的必要性尚无共识,因此进行本研究以确定异常凝血状态是否会影响TCCVC牵引拔除后的止血时间(TH)。
转诊至我们团队要求拔除经颈内或锁骨下途径置入的TCCVC的成年患者被视为纳入对象。采集血液以评估凝血酶原时间(PT)和国际标准化比值(INR)、活化部分凝血活酶时间(aPTT)及血小板计数。采用牵引技术拔除导管,并在手动压迫的5分钟间隔时评估止血情况。
在2001年11月19日至2004年4月20日期间,179名受试者入组并完成研究。165名受试者的TH在首个5分钟间隔内,14名受试者需要超过5分钟。与TH延长相关的具有统计学意义的因素为终末期肾病的初步诊断(P = 0.005)、使用抗血小板药物(P = 0.03)以及由“低容量”操作者进行操作(P = 0.002)。
常规拔除前评估凝血参数没有必要。血小板功能可能异常但血小板数量正常的患者似乎有TH延长的风险,但即使在这些情况下,TH很少超过15分钟。