耐抗生素革兰氏阴性菌的当前概念

Current concepts in antibiotic-resistant gram-negative bacteria.

作者信息

Torres Julián Andrés, Villegas Maria Virginia, Quinn John P

机构信息

CIDEIM (International Center for Medical Research and Training), Avenida 1N # 3-03, Cali, Colombia.

出版信息

Expert Rev Anti Infect Ther. 2007 Oct;5(5):833-43. doi: 10.1586/14787210.5.5.833.

DOI:10.1586/14787210.5.5.833

PMID:17914917

Abstract

Gram-negative bacteria are the dominant killers among bacterial pathogens in the intensive care unit. Antibiotic resistance has become a threat in hospital settings and efforts are being made to understand the underlying mechanisms. This review describes current data on the most important mechanisms of resistance in prevalent gram-negative pathogens as well as newer therapeutic options.

摘要

革兰氏阴性菌是重症监护病房中细菌性病原体的主要杀手。抗生素耐药性已成为医院环境中的一大威胁，人们正在努力了解其潜在机制。本综述描述了关于常见革兰氏阴性病原体最重要耐药机制的当前数据以及新的治疗选择。