获得性无巨核细胞性血小板减少症和纯红细胞再生障碍性贫血与隐匿性大颗粒淋巴细胞白血病相关。
Acquired amegakaryocytic thrombocytopenia and pure red cell aplasia associated with an occult large granular lymphocyte leukemia.
作者信息
Lai Dominic W, Loughran Thomas P, Maciejewski Jaroslaw P, Sasu Sebastian, Song Sophie X, Epling-Burnette P K, Paquette Ronald L
机构信息
VA Greater Los Angeles Health Care System, Los Angeles, CA 90095-1678, United States.
出版信息
Leuk Res. 2008 May;32(5):823-7. doi: 10.1016/j.leukres.2007.08.012. Epub 2007 Oct 29.
Acquired amegakaryocytic thrombocytopenia and pure red cell aplasia rarely occur concurrently. We report a case in which these disorders were associated with an occult large granular lymphocyte leukemia. The peripheral blood cytopenias improved after glucocorticoids and intravenous immunoglobulin were administered, and response was maintained with cyclosporine. Large granular lymphocyte leukemia should be suspected in the setting of unexplained bone marrow failure.
获得性无巨核细胞性血小板减少症和纯红细胞再生障碍性贫血很少同时发生。我们报告了一例这些病症与隐匿性大颗粒淋巴细胞白血病相关的病例。给予糖皮质激素和静脉注射免疫球蛋白后，外周血细胞减少有所改善，并用环孢素维持缓解。在不明原因的骨髓衰竭情况下，应怀疑大颗粒淋巴细胞白血病。
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