Olson Steven A, Kadrmas Michael W, Hernandez Jon D, Glisson Richard R, West Jesse L
Division of Orthopaedic Surgery, Duke University Medical Center, Durham, NC 27710, USA.
J Orthop Trauma. 2007 Oct;21(9):608-16. doi: 10.1097/BOT.0b013e3181591397.
This study investigates if the use of calcium phosphate cement as an adjunct to internal fixation for posterior wall acetabular fracture will result in acute restoration of joint loading parameters to the intact condition.
Ten fresh-frozen cadaveric pelves were used for this investigation. Simulated abductor mechanism was used to load the hip. Pressure-sensitive film was used to measure contact area and pressure within the anterior, superior, and posterior regions of the acetabulum for all experimental conditions. The hips were loaded under the following 4 conditions: 1) intact; 2) following posterior wall osteotomy; 3) following reduction and standard internal fixation; and 4) following reduction of the posterior wall using calcium phosphate cement, as a grout, in addition to internal fixation. A posterior wall fracture was created along an arc of 40-90 degrees about the acetabular rim. Extensometers were utilized to measure posterior wall fragment micromotion under conditions 3 and 4 above. Statistical analysis was performed using multivariate analysis of variance to assess the significance of the difference among and between conditions simultaneously for each region. Fragment motion data were analyzed using a 2-tailed t test.
Fragment micromotion was reduced to 78 microm superiorly and 46 microm inferiorly with the use of calcium phosphate cement (P < 0.05). Creation of a posterior wall defect resulted in increased load in the superior acetabulum (1201N) as compared to the intact condition (902N, P = 0.024). Following reduction and internal fixation, the load distributed to the superior acetabulum (1132N) was not statistically different from the displaced condition. Following the addition of calcium phosphate cement, the load seen at the superior region of the acetabulum (883N) was less than fixation without calcium phosphate cement and was not different from the intact state (P = 0.85).
The use of calcium-phosphate cement as a fracture grout with internal fixation resulted in a partial restoration of joint loading parameters toward the intact state. Further work will be needed to determine if similar types of augmented articular fixation may result in a clinical benefit.
本研究旨在调查使用磷酸钙骨水泥辅助内固定治疗髋臼后壁骨折是否能使关节负荷参数迅速恢复至完整状态。
本研究使用了10具新鲜冷冻的尸体骨盆。采用模拟外展肌机制对髋关节进行加载。在所有实验条件下,使用压敏膜测量髋臼前、上、后区域的接触面积和压力。髋关节在以下4种条件下加载:1)完整状态;2)后壁截骨后;3)复位并进行标准内固定后;4)复位后壁后,除内固定外,使用磷酸钙骨水泥作为灌浆材料。沿髋臼边缘40 - 90度的弧线制造后壁骨折。在上述条件3和4下,使用引伸计测量后壁骨折块的微动。使用多因素方差分析进行统计分析,以同时评估各区域不同条件之间差异的显著性。骨折块运动数据采用双侧t检验进行分析。
使用磷酸钙骨水泥后,骨折块微动在上方减少至78微米,下方减少至46微米(P < 0.05)。与完整状态(902N)相比,后壁缺损导致髋臼上方负荷增加(1201N,P = 0.024)。复位并内固定后,髋臼上方分布的负荷(1132N)与移位状态相比无统计学差异。添加磷酸钙骨水泥后,髋臼上方区域的负荷(883N)小于未使用磷酸钙骨水泥的固定情况,且与完整状态无差异(P = 0.85)。
使用磷酸钙骨水泥作为骨折灌浆材料并结合内固定可使关节负荷参数部分恢复至完整状态。需要进一步开展工作以确定类似类型的增强关节固定是否能带来临床益处。