T-bet的缺失会破坏宿主与微生物之间的共生关系。

Loss of T-bet sends host-microbe mutualism awry.

作者信息

Ma Averil

机构信息

Department of Medicine, Program in Biomedical Sciences, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0451, USA.

出版信息

Cell. 2007 Oct 5;131(1):15-7. doi: 10.1016/j.cell.2007.09.030.

DOI:10.1016/j.cell.2007.09.030

PMID:17923080

Abstract

Immune homeostasis in the intestine involves complex interactions between microbial organisms and host cells. In this issue, Garrett et al. (2007) describe a communicable form of colitis that is induced by deficiency of the transcription factor T-bet in cells of the innate immune system.

摘要

肠道中的免疫稳态涉及微生物与宿主细胞之间的复杂相互作用。在本期中，加勒特等人（2007年）描述了一种由先天性免疫系统细胞中转录因子T-bet缺乏引起的可传播性结肠炎。