120例韩国法医尸检病例中意外发现的垂体微腺瘤的特征

The characteristics of incidental pituitary microadenomas in 120 Korean forensic autopsy cases.

作者信息

Kim Jang Hee, Seo Jung Seok, Lee Bong Woo, Lee Sang Young, Jeon Seok Hoon, Lee Kyi Beom

机构信息

Department of Pathology, Ajou University School of Medicine, Suwon, Korea.

出版信息

J Korean Med Sci. 2007 Sep;22 Suppl(Suppl):S61-5. doi: 10.3346/jkms.2007.22.S.S61.

DOI:10.3346/jkms.2007.22.S.S61

PMID:17923757

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2694400/

Abstract

To investigate the characteristics of incidental pituitary microadenomas, we examined 120 pituitary glands from Korean forensic autopsy cases, from which eight tumors were identified (incidence 6.7%). The average age of the affected subjects was 50 yr (range: 33-96 yr) with a female predominance. The maximum diameters of the tumors ranged from 0.4 to 5.4 mm (mean: 2.8 mm). Immunohistochemical analysis of pituitary hormones revealed three growth hormone-secreting adenomas, one prolactin-producing adenoma, one gonadotropin-producing adenoma, one plurihormonal adenoma, and two null cell adenomas. MIB-1 staining for Ki-67 antigen showed no positive expression. The microvessel density (MVD) of the pituitary microadenomas ranged from 2.3 to 11.6% (mean: 5.3%) and was significantly lower than that of nonneoplastic pituitary glands (11.9-20.1%, mean: 14.8%). Our study provides reference data on incidental pituitary microadenomas in the Korean population.

摘要

为研究垂体微腺瘤的特征，我们检查了120例韩国法医尸检病例的垂体，从中发现了8例肿瘤（发病率6.7%）。受影响受试者的平均年龄为50岁（范围：33 - 96岁），女性居多。肿瘤的最大直径为0.4至5.4毫米（平均：2.8毫米）。垂体激素的免疫组织化学分析显示，有3例生长激素分泌型腺瘤、1例催乳素分泌型腺瘤、1例促性腺激素分泌型腺瘤、1例多激素腺瘤和2例无功能细胞腺瘤。Ki-67抗原的MIB-1染色未显示阳性表达。垂体微腺瘤的微血管密度（MVD）为2.3%至11.6%（平均：5.3%），显著低于非肿瘤性垂体（11.9% - 20.1%，平均：14.8%）。我们的研究为韩国人群中偶然发现的垂体微腺瘤提供了参考数据。