向列相的手性掺杂及其在绝对构型测定中的应用。

Chiral doping of nematic phases and its application to the determination of absolute configuration.

作者信息

Pieraccini Silvia, Ferrarini Alberta, Spada Gian Piero

机构信息

Alma Mater Studiorum-Università di Bologna, Dipartimento di Chimica Organica A. Mangini,via San Giacomo 11, I-40126 Bologna, Italy.

出版信息

Chirality. 2008 May 15;20(5):749-59. doi: 10.1002/chir.20482.

DOI:10.1002/chir.20482

PMID:17924420

Abstract

Doping nematic liquid crystals with nonracemic chiral compounds induces a twisted nematic (cholesteric) phase. The ability of solutes to twist the nematic phase may be related to the overall shape of the chiral dopant and consequently to its absolute configuration. The cholesteric induction is therefore a powerful tool complementary to chiroptical techniques to obtain stereochemical information on chiral molecules.

摘要

用非外消旋手性化合物掺杂向列型液晶会诱导出扭曲向列相（胆甾相）。溶质使向列相发生扭曲的能力可能与手性掺杂剂的整体形状有关，进而与其绝对构型有关。因此，胆甾相诱导是一种强大的工具，可作为圆二色光谱技术的补充，用于获取手性分子的立体化学信息。