刺猬信号通路。
Hedgehog signaling pathway.
作者信息
Jacob Leni, Lum Lawrence
机构信息
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
出版信息
Sci STKE. 2007 Oct 9;2007(407):cm6. doi: 10.1126/stke.4072007cm6.
PMID:17925577
Abstract
The Hedgehog (Hh) signaling pathway is essential for development and tissue homeostasis in metazoans. Probably as a result of its potent influence on cell-fate outcomes, the Hh pathway when corrupted results in malformations and diseases such as cancer. Many of the pathway components that contribute to Hh-mediated signal transduction are presented.
摘要
刺猬索尼克（Hh）信号通路对于后生动物的发育和组织稳态至关重要。可能由于其对细胞命运结果的强大影响，Hh通路一旦受损就会导致畸形和癌症等疾病。文中介绍了许多参与Hh介导的信号转导的通路成分。
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