盐酸尼非卡兰成功用于先天性心脏手术术后交界性异位性心动过速的治疗

[Successful administration of nifekalant hydrochloride for postoperative junctional ectopic tachycardia in congenital cardiac surgery].

作者信息

Sasaki Tomoyasu, Nemoto S, Ozawa H, Katsumata T, Ozaki N, Okumura K, Katayama H, Tamai H, Kishida H

机构信息

Department of Cardiovascular Surgery, Osaka Medical College, Takatsuki, Japan.

出版信息

Kyobu Geka. 2007 Oct;60(11):1022-6.

PMID:17926908

Abstract

Two episode of junctional ectopic tachycardia (JET) caused hemodynamic deterioration early after tetralogy of Fallot repair in an 8-month-old infant. Sinus rhythm resumed in each of the episodes immediately after intravenous administration of nifekalant hydrochloride (NIF), a newly developed Vaughan-Williams class III antiarrhythmic drug in Japan. Although QT interval was modestly prolonged with NIF, no life-threatening ventricular arrhythmia (i.e., torsades de pointes) occurred. NIF might be an effective alternative in the treatment of postoperative JET in congenital cardiac surgery.

摘要

一名8个月大的婴儿在法洛四联症修复术后早期，两次交界性异位性心动过速（JET）发作导致血流动力学恶化。在静脉注射日本新开发的III类抗心律失常药物盐酸尼非卡兰（NIF）后，每次发作均立即恢复窦性心律。尽管使用NIF后QT间期有适度延长，但未发生危及生命的室性心律失常（即尖端扭转型室速）。NIF可能是先天性心脏手术术后JET治疗的一种有效替代药物。