中度至重度阻塞性睡眠呼吸暂停患者经6个月持续气道正压通气治疗后心率变异性的恢复情况。

Recovery of heart rate variability in patients with moderate to severe obstructive sleep apnea after 6-month continuous positive airway pressure treatment.

作者信息

Limphanudom Pimporn, Chierakul Nitipatana, Pinyopattarakul Narongsak, Nana Arth, Naruman Chana, Tangchityongsiva Suwat, Wattanapa Wattana B, Jenwitheesak Anorut

机构信息

Division of Respiratory Disease and Tuberculosis, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

出版信息

J Med Assoc Thai. 2007 Aug;90(8):1530-5.

PMID:17926981

Abstract

OBJECTIVE

To evaluate the effect of long-term treatment with continuous positive airway pressure (CPAP) on the heart rate variability (HRV) of obstructive sleep apnea (OSA) patients.

MATERIAL AND METHOD

Patients with moderate to severe OSA who had never used CPAP treatment were enrolled. Short recording HRV analysis was performed at baseline then at one, three, and six months after CPAP treatment. The measurement included low frequency HRV (LF), high frequency HRV (HF), low frequency to high frequency ratio (LHR), and standard deviation of R-R intervals (SDNN). All domains were measured both during spontaneous and deep breathing.

RESULTS

There were 10 patients in the present study, all were men with the mean age of 45 years, mean body mass index 29.3 kg/m2, mean apnea-hypopnea index 60.9 events/hour, and mean average CPAP usage 4.8 hours/night. The HRV showed no significant change after one and three months of CPAP treatment. At 6 months, the only significant change was the SDNN measured after deep breathing (28.80 +/- 9.83 vs. 34.43 +/- 14.23 millisecond, p = 0.032).

CONCLUSION

One aspect of heart rate variability in moderate to severe obstructive sleep apnea patients was improved after six month's continuous positive airway pressure treatment.

摘要

目的

评估持续气道正压通气（CPAP）长期治疗对阻塞性睡眠呼吸暂停（OSA）患者心率变异性（HRV）的影响。

材料与方法

纳入从未使用过CPAP治疗的中度至重度OSA患者。在基线时以及CPAP治疗后1个月、3个月和6个月进行短程HRV分析记录。测量指标包括低频HRV（LF）、高频HRV（HF）、低频与高频比值（LHR）以及R-R间期标准差（SDNN）。所有指标均在自主呼吸和深呼吸时进行测量。

结果

本研究共纳入10例患者，均为男性，平均年龄45岁，平均体重指数29.3kg/m²，平均呼吸暂停低通气指数60.9次/小时，平均每晚CPAP使用时间4.8小时。CPAP治疗1个月和3个月后HRV无显著变化。6个月时，唯一显著的变化是深呼吸后测量的SDNN（28.80±9.83对34.43±14.23毫秒，p = 0.032）。