垂体肿瘤转化基因（PTTG）在内分泌肿瘤发生中的新作用。

The emerging role of pituitary tumour transforming gene (PTTG) in endocrine tumourigenesis.

作者信息

Kim D S, Fong J, Read M L, McCabe C J

机构信息

Institute of Biomedical Research, Division of Medical Sciences, University of Birmingham, Birmingham B15 2TH, UK.

出版信息

Mol Cell Endocrinol. 2007 Nov 15;278(1-2):1-6. doi: 10.1016/j.mce.2007.08.006. Epub 2007 Aug 28.

DOI:10.1016/j.mce.2007.08.006

PMID:17928133

Abstract

It is now 10 years since PTTG was first cloned and isolated. Perhaps the major story of the intervening decade of work performed by numerous groups around the world is the sheer multifunctionality ascribed to this gene. PTTG has been implicated in mechanisms of gene transactivation, cell transformation, angiogenesis, metabolism, apoptosis, DNA repair, genetic instability and mitotic control, both in endocrine and non-endocrine settings. In the current review, we cast a critical eye over a decade of PTTG research within the field of endocrine neoplasia.

摘要

自PTTG首次被克隆和分离至今已有10年。在这十年间，世界各地众多研究团队开展了大量工作，其中最主要的发现或许就是PTTG具有多种功能。在内分泌和非内分泌环境中，PTTG都与基因反式激活、细胞转化、血管生成、代谢、凋亡、DNA修复、基因不稳定及有丝分裂控制等机制有关。在本综述中，我们对内分泌肿瘤领域内十年的PTTG研究进行了批判性审视。