Chang Shih-Heng, Lee Chien-Chang, Chen Shey-Ying, Chen I-Chung, Hsieh Ming-Ru, Chen Shyr-Chyr
Department of Emergency Medicine, National Taiwan University Hospital, Taipei 100, Taiwan.
Diagn Microbiol Infect Dis. 2008 Feb;60(2):201-4. doi: 10.1016/j.diagmicrobio.2007.09.002. Epub 2007 Oct 24.
Infectious intracranial aneurysms (IIAs) are uncommon but severe complications of bacterial endocarditis. We report a case of IIA due to a rare nutritionally variant streptococcus, Granulicatella adiacens. The 31-year-old young patient, without any known risk for infective endocarditis had a silent clinical course until rupture of IIAs occurred. Despite antibiotic treatment and surgical clipping of IIAs, a second episode of more severe intracerebral hemorrhage occurred four months later. Mitral valvuloplasty was undertaken and there were no more brain insults in the following four years. Awareness of the possibility of hemorrhagic stroke as the initial presentation of Granulicatella adiacens endocarditis, and the possibility of high recurrence and bacteriological failure rate of Granulicatella adiacens infection may be helpful in early diagnosis and surgical decision, thus limiting future fatal complications.
感染性颅内动脉瘤(IIA)虽不常见,但却是细菌性心内膜炎的严重并发症。我们报告一例由罕见的营养变异型链球菌——毗邻颗粒链菌引起的IIA病例。该31岁年轻患者无任何已知的感染性心内膜炎风险因素,在IIA破裂前临床过程隐匿。尽管对IIA进行了抗生素治疗和手术夹闭,但四个月后发生了更严重的第二次脑出血。患者接受了二尖瓣成形术,在随后四年中未再发生脑部损伤。认识到出血性中风可能是毗邻颗粒链菌心内膜炎的首发表现,以及毗邻颗粒链菌感染可能具有高复发率和细菌学失败率,这可能有助于早期诊断和手术决策,从而限制未来的致命并发症。