β-连环蛋白黏附与信号功能的磷酸化调控
Phospho-regulation of Beta-catenin adhesion and signaling functions.
作者信息
Daugherty Rebecca Leadem, Gottardi Cara J
机构信息
The Integrated Graduate Program in the Life Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
出版信息
Physiology (Bethesda). 2007 Oct;22:303-9. doi: 10.1152/physiol.00020.2007.
Abstract
Beta-catenin plays a critical structural role in cadherin-based adhesions and is also an essential co-activator of Wnt-mediated gene expression. The degree to which beta-catenin participates in these two functions is dictated by the availability of beta-catenin binding partners, and an emerging theme is that these binding interactions are regulated by phosphorylation. Inputs from various cell-signaling events can therefore impact beta-catenin function, which may be necessary for the finely tuned adhesive and signaling responses required for tissue morphogenesis.
摘要
β-连环蛋白在基于钙黏蛋白的黏附中发挥关键的结构作用，并且也是Wnt介导的基因表达所必需的共激活因子。β-连环蛋白参与这两种功能的程度取决于β-连环蛋白结合伴侣的可获得性，并且一个新出现的主题是这些结合相互作用受磷酸化调节。因此，来自各种细胞信号事件的输入可以影响β-连环蛋白的功能，这对于组织形态发生所需的精细调节的黏附及信号反应可能是必要的。
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