25至64岁男性的抑郁症与心血管疾病风险（世界卫生组织莫尼卡项目——社会心理因素）

Depression and risk of cardiovascular diseases among males aged 25-64 (WHO MONICA--psychosocial).

作者信息

Gromova H A, Gafarov V V, Gagulin I V

机构信息

Collaborative Laboratory of Epidemiology of Cardiovascular Diseases (Institute of Internal Medicine, Novosibirsk, Russia.

出版信息

Alaska Med. 2007;49(2 Suppl):255-8.

PMID:17929644

Abstract

OBJECTIVE

To study the influence of depression on risk of cardiovascular diseases development during 10 years in non-organized male population aged 25-64.

STUDY DESIGN AND METHODS

Within the framework of the MONICA--psychosocial program a representative sample of 657 men 25-64 years old (1994 year) was examined. Depression was measured at baseline with the use of the MONICA--psychosocial Interview Depression scale. The incidence of new cases of AH, MI and stroke was revealed in the WHO "Registry MI" and "Registry stroke" 10-year follow-up. Cox is a proportional regression model that was used for estimation of RR.

RESULTS

The proportion of depression in the cohort of men with AH was 28.9%, with MI--65.8% and of men with stroke 70.6%. The relative risk of development of AH, MI, stroke during the first five years of supervision in a group with the high level of depression as compared to those in whom depression was not observed was 6.7 times (p < 0.01), 2.26 times (p < 0.05), 6.4 times higher (p < 0.01), respectively. Within 10 years, the risk of development of cardiovascular diseases in men with high level of depression was: for AH--RR = 4.2; for MI--RR = 2.4; and stroke--RR = 5.2 (p < 0.05 comparing to those without it.

CONCLUSION

Depression is a predictor of cardiovascular diseases in middle-aged men.

摘要

目的

研究抑郁症对25 - 64岁无组织男性人群10年内心血管疾病发生风险的影响。

研究设计与方法

在莫妮卡（MONICA）——社会心理项目框架内，对657名25 - 64岁男性（1994年）的代表性样本进行了检查。在基线时使用莫妮卡——社会心理访谈抑郁量表测量抑郁症。在世界卫生组织“心肌梗死登记处”和“中风登记处”10年随访中揭示了高血压、心肌梗死和中风新病例的发生率。Cox比例回归模型用于估计相对风险（RR）。

结果

高血压男性队列中抑郁症的比例为28.9%，心肌梗死男性中为65.8%，中风男性中为70.6%。与未观察到抑郁症的人群相比，在抑郁症高水平组中，前五年监测期间高血压、心肌梗死、中风发生的相对风险分别高6.7倍（p < 0.01）、2.26倍（p < 0.05）、6.4倍（p < 0.01）。在10年内，抑郁症高水平男性患心血管疾病的风险为：高血压——RR = 4.2；心肌梗死——RR = 2.4；中风——RR = 5.2（与无抑郁症者相比，p < 0.05）。