喂食不同胆固醇含量饮食的非人灵长类动物血清脂质和脂蛋白的系统发育变异性

Phylogenetic variability of serum lipids and lipoproteins in non-human primates fed diets with different contents of dietary cholesterol.

作者信息

Srinivasan S R, Smith C C, Radhakrishnamurthy B, Wolf R H, Berenson G S

出版信息

Adv Exp Med Biol. 1976;67(00):65-75. doi: 10.1007/978-1-4614-4618-7_3.

Abstract

The response of serum lipids and lipoproteins to different levels of dietary cholesterol (0.05% to 1.5% w/w) was measured in six nonhuman primate species. Relative response of serum cholesterol in different species, measured in terms of response, index, varied with dietary cholesterol concentration. The overall response for the different diets allowed ranking of the species as follows: Squirrel is greater than green is greater then spider is approximately thesus is approximately patas is greater than chimpanzee The serum cholesterol response was reflected not only in an increase in beta + pre-beta-lipoprotein cholesterol but also in alpha-lipoprotein cholesterol, with significant differences among species in the amount of cholesterol transported in the lipoprotein classes.

摘要

在六种非人类灵长类动物中测量了血清脂质和脂蛋白对不同水平膳食胆固醇（0.05%至1.5% w/w）的反应。以反应指数衡量，不同物种血清胆固醇的相对反应随膳食胆固醇浓度而变化。不同饮食的总体反应使这些物种的排名如下：松鼠猴大于绿猴大于蜘蛛猴约等于猕猴约等于粗尾猿大于黑猩猩。血清胆固醇反应不仅体现在β+前β-脂蛋白胆固醇增加，也体现在α-脂蛋白胆固醇增加，不同物种在脂蛋白类别中运输的胆固醇量存在显著差异。