Thurm D A, Samonds K W, Hegsted D M
Am J Clin Nutr. 1976 Jun;29(6):621-5. doi: 10.1093/ajcn/29.6.621.
Using an atlas constructed from records of a group of normal monkeys in the same colony, the effects of a 20-week low-calorie or low-protein nutritional insult on skeletal development were determined. The most significantly retarded sites were the late-forming ossifications (epiphyses, sesamoids, and tuberosites). A general increase in ossification anomalies and in individual variation was evident. The similarity of these findings to studies previously reported for man indicates the utility of nonhuman primate models for the further study of nutritional deficiency.
利用从同一猴群正常猴子记录构建的图谱,确定了为期20周的低热量或低蛋白营养损伤对骨骼发育的影响。受影响最显著的部位是形成较晚的骨化部位(骨骺、籽骨和结节)。骨化异常和个体差异普遍增加。这些发现与先前报道的人类研究结果相似,表明非人类灵长类动物模型在进一步研究营养缺乏方面具有实用性。