[微小RNA与干细胞的研究进展]
[Research advance of microRNA and stem cell].
作者信息
Gao Jie, Yang Tongtao, Qiu Xiuchun
机构信息
Department of Orthopedic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an Shaanxi, 710038, PR China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2007 Sep;21(9):1007-10.
OBJECTIVE
To review the advance in the experimental studies of microRNA (miRNA) and the relationship between miRNA and stem cells.
METHODS
The related literature was reviewed, and the research findings of miRNA and stem cell were summarized.
RESULTS
miRNA was non-coding small RNA (20-25 nt) involved in post-transcriptional change, that have been shown to regulate gene expressions. It has been reported that some kinds of miRNAs were likely important regulators for stem cells maintaining their state of self-renewal, and play key roles in their differentiation.
CONCLUSION
miRNA as regulation of gene expressions, can be served as a new way for stem cells research.
目的
综述微小RNA（miRNA）的实验研究进展以及miRNA与干细胞之间的关系。
方法
查阅相关文献，总结miRNA和干细胞的研究成果。
结果
miRNA是参与转录后变化的非编码小RNA（20 - 25个核苷酸），已被证明可调节基因表达。据报道，某些种类的miRNA可能是干细胞维持自我更新状态的重要调节因子，并在其分化中起关键作用。
结论
miRNA作为基因表达的调节因子，可为干细胞研究提供一种新途径。
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