Lobo Mary Kay, Cui Yijun, Ostlund Sean B, Balleine Bernard W, Yang X William
Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience & Human Behavior, University of California at Los Angeles, 695 Charles Young Drive South, Los Angeles, California 90095, USA.
Nat Neurosci. 2007 Nov;10(11):1395-7. doi: 10.1038/nn1987. Epub 2007 Oct 14.
Instrumental conditioning allows animals to learn about the consequences of their own actions, but the underpinning molecular mechanisms remain elusive. Here we show that the sphingosine-1-phosphate (S1P) receptor Gpr6 is selectively expressed in the striatopallidal neurons in the striatum. Gpr6-deficient mice showed reduced striatal cyclic AMP production in vitro and selective alterations in instrumental conditioning in vivo. Thus, Gpr6 is the first striatopallidal neuron-specific genetic regulator of instrumental conditioning in a mammal.
工具性条件反射使动物能够了解自身行为的后果，但其潜在的分子机制仍然难以捉摸。在这里，我们表明鞘氨醇-1-磷酸（S1P）受体Gpr6在纹状体的纹状体苍白球神经元中选择性表达。Gpr6基因敲除小鼠在体外表现出纹状体环磷酸腺苷生成减少，在体内工具性条件反射方面出现选择性改变。因此，Gpr6是哺乳动物中第一个工具性条件反射的纹状体苍白球神经元特异性基因调节因子。
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