使用三氟甲磺酸2-苄氧基-1-甲基吡啶鎓合成苄酯。

Synthesis of benzyl esters using 2-benzyloxy-1-methylpyridinium triflate.

作者信息

Tummatorn Jumreang, Albiniak Philip A, Dudley Gregory B

机构信息

Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306-4390, USA.

出版信息

J Org Chem. 2007 Nov 9;72(23):8962-4. doi: 10.1021/jo7018625. Epub 2007 Oct 13.

DOI:10.1021/jo7018625

PMID:17935354

Abstract

Triethylamine (Et3N) mediates esterification reactions between the title reagent (1) and carboxylic acids. Alcohols, phenols, amides, and other sensitive functionality are not affected; a dual role for Et3N as a promoter and a scavenger is postulated. Benzyl esters are obtained from substrates including amino acid and sugar derivatives.

摘要

三乙胺（Et3N）介导标题试剂（1）与羧酸之间的酯化反应。醇、酚、酰胺及其他敏感官能团不受影响；推测三乙胺兼具促进剂和清除剂的双重作用。苄酯可从包括氨基酸和糖衍生物在内的底物中获得。