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直接在时域中对包括生物组织色散特性在内的生物组织超声瞬态散射进行建模。

Modeling ultrasonic transient scattering from biological tissues including their dispersive properties directly in the time domain.

作者信息

Norton G V, Novarini J C

机构信息

Naval Research Laboratory, Stennis Space Center, MS, USA.

出版信息

Mol Cell Biomech. 2007 Jun;4(2):75-85.

Abstract

Ultrasonic imaging in medical applications involves propagation and scattering of acoustic waves within and by biological tissues that are intrinsically dispersive. Analytical approaches for modeling propagation and scattering in inhomogeneous media are difficult and often require extremely simplifying approximations in order to achieve a solution. To avoid such approximations, the direct numerical solution of the wave equation via the method of finite differences offers the most direct tool, which takes into account diffraction and refraction. It also allows for detailed modeling of the real anatomic structure and combination/layering of tissues. In all cases the correct inclusion of the dispersive properties of the tissues can make the difference in the interpretation of the results. However, the inclusion of dispersion directly in the time domain proved until recently to be an elusive problem. In order to model the transient signal a convolution operator that takes into account the dispersive characteristics of the medium is introduced to the linear wave equation. To test the ability of this operator to handle scattering from localized scatterers, in this work, two-dimensional numerical modeling of scattering from an infinite cylinder with physical properties associated with biological tissue is calculated. The numerical solutions are compared with the exact solution synthesized from the frequency domain for a variety of tissues having distinct dispersive properties. It is shown that in all cases, the use of the convolutional propagation operator leads to the correct solution for the scattered field.

摘要

医学应用中的超声成像涉及声波在本质上具有色散性的生物组织内部的传播以及由生物组织引起的散射。对非均匀介质中的传播和散射进行建模的分析方法很困难,并且通常需要极其简化的近似才能得到解。为了避免这种近似,通过有限差分法对波动方程进行直接数值求解提供了最直接的工具,该方法考虑了衍射和折射。它还允许对真实解剖结构以及组织的组合/分层进行详细建模。在所有情况下,正确纳入组织的色散特性会对结果的解释产生影响。然而,直到最近,在时域中直接纳入色散仍是一个难以解决的问题。为了对瞬态信号进行建模,将一个考虑介质色散特性的卷积算子引入线性波动方程。为了测试该算子处理来自局部散射体散射的能力,在这项工作中,计算了具有与生物组织相关物理特性的无限长圆柱散射的二维数值模型。将数值解与从频域合成的针对具有不同色散特性的各种组织的精确解进行了比较。结果表明,在所有情况下,使用卷积传播算子都能得到散射场的正确解。

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