Romero Otero Javier, Martínez-Salamanca Juan I
Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, USA.
Arch Esp Urol. 2007 Sep;60(7):767-76. doi: 10.4321/s0004-06142007000700006.
Radical prostatectomy is worldwide accepted as treatment for clinically localized prostate cancer. Its oncological results are excellent, so nowadays the functional outcomes: continence and potency, have become essential factors when evaluating the results. Open radical prostatectomy (ORP) is the gold standard against the new techniques, Laparoscopic (LRP) and robotic (RRP) must be compared. A systematic review of the literature is done to evaluate functional outcomes between the three approaches.
Systematic review in the databases: PubMed; EMBASE; Cochrane; SCOPUS; Science Citation Index for: "radical retropubic prostatectomy", "open radical prostatectomy"; "laparoscopic prostatectomy"; "laparoscopic radical prostatectomy"; "robotic prostatectomy"; "robotic radical prostatectomy and functional assessment"; "continence"; "urinary function"; "incontinence"; "erectile function"; 'sexual function"; "quality of life"; "functional assessment"; "minimally invasive treatment was performed".
The lack of randomized trials for this issue forces us to evaluate the functional results comparing the most important series of each approach, so the value of the results are very limited. Accepting 0 pads per day as continence definition and evaluated 12 months following surgery, the continence rates for each approach ORP, LRP and RRP are respectively: 8 1% (60-93%); 87% (82-95%) and 91% (84-98%). For erectile function admitting the capability for intercourse as potency definition, with or without the use of oral drugs and evaluated 12 months following surgery; the potency rates for each approach are: 68% (62-75%), 69% (52-78%) y 60% (20-97%).
Due the lack of randomized trials, we have to evaluate the most important contemporaneous series. The lack of homogeneity in evaluating and reporting results is evident in the urological community. With the limitations of the data available it seems to exist no differences between the three groups for functional outcomes. It is mandatory to develop randomized trials and achieve a consensus for the criteria at the time of evaluating the functional outcomes.
根治性前列腺切除术是全球公认的临床局限性前列腺癌的治疗方法。其肿瘤学效果极佳,因此如今在评估治疗结果时,功能结局(控尿和性功能)已成为关键因素。必须将开放性根治性前列腺切除术(ORP)这一新技术的金标准与腹腔镜根治性前列腺切除术(LRP)和机器人辅助根治性前列腺切除术(RRP)进行比较。我们对文献进行了系统综述,以评估这三种手术方式的功能结局。
在PubMed、EMBASE、Cochrane、SCOPUS、科学引文索引等数据库中进行系统综述,检索词为:“耻骨后根治性前列腺切除术”、“开放性根治性前列腺切除术”、“腹腔镜前列腺切除术”、“腹腔镜根治性前列腺切除术”、“机器人前列腺切除术”、“机器人根治性前列腺切除术及功能评估”、“控尿”、“排尿功能”、“尿失禁”、“勃起功能”、“性功能”、“生活质量”、“功能评估”、“进行了微创治疗”。
由于缺乏针对该问题的随机试验,我们不得不通过比较每种手术方式最重要的系列研究来评估功能结果,因此结果的价值非常有限。将每天使用0片尿垫定义为控尿,并在术后12个月进行评估,ORP、LRP和RRP三种手术方式的控尿率分别为:81%(60 - 93%)、87%(82 - 95%)和91%(84 - 98%)。对于勃起功能,将能够进行性交定义为性功能,无论是否使用口服药物,并在术后12个月进行评估;三种手术方式的性功能恢复率分别为:68%(62 - 75%)、69%(52 - 78%)和60%(20 - 97%)。
由于缺乏随机试验,我们不得不评估最重要的同期系列研究。泌尿外科界在评估和报告结果方面缺乏同质性是显而易见的。鉴于现有数据的局限性,三种手术方式在功能结局方面似乎没有差异。开展随机试验并就评估功能结局时的标准达成共识是很有必要的。