非同源末端连接中的DNA依赖性蛋白激酶：一把有多个钥匙的锁？
DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?
作者信息
Weterings Eric, Chen David J
机构信息
Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
出版信息
J Cell Biol. 2007 Oct 22;179(2):183-6. doi: 10.1083/jcb.200705106. Epub 2007 Oct 15.
Abstract
The DNA-dependent protein kinase (DNA-PK) is one of the central enzymes involved in DNA double-strand break (DSB) repair. It facilitates proper alignment of the two ends of the broken DNA molecule and coordinates access of other factors to the repair complex. We discuss the latest findings on DNA-PK phosphorylation and offer a working model for the regulation of DNA-PK during DSB repair.
摘要
DNA依赖性蛋白激酶（DNA-PK）是参与DNA双链断裂（DSB）修复的核心酶之一。它促进断裂DNA分子两端的正确对齐，并协调其他因子进入修复复合体。我们讨论了关于DNA-PK磷酸化的最新发现，并提出了一个在DSB修复过程中调控DNA-PK的工作模型。
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