[Effects of zixoryn on pharmacokinetics of antipyrine in intact and sensitized guinea pigs].
作者信息
Khlopushina T G, Krinskaia A V, Kovalenko L P, Zherdev V P, Val'dman A V
出版信息
Biull Eksp Biol Med. 1991 Jul;112(7):67-9.
PMID:1793861
Abstract
The effect of zixoryn, a hepatic inductor of cytochrome P-450, on the pharmacokinetics of antipyrine in intact and sensibilized guinea-pigs was studied. It was found that sensibilization of albumin increased the half-time (T1/2), AUC and decreased the total body clearance (Clt) of antipyrine and the renal clearance (Clr) of metabolites in urine. The administration of zixoryn in sensibilized animals decreased T1/2 and AUC and increased the clearance of antipyrine and its metabolites.
摘要
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