Nicholson Bruce, Passik Steven D
Pain Specialists of Greater Lehigh Valley, Allentown, PA 18103, USA.
South Med J. 2007 Oct;100(10):1028-36. doi: 10.1097/SMJ.0b013e3180f626ff.
While opioids are regarded as the mainstay of chronic pain management, their use is controversial in the minds of many primary care physicians due to clinical concerns about dependence, abuse, and addiction and medicolegal concerns regarding state and federal regulatory authorities. For patients with moderate to moderately severe pain, the treatment of choice is a long-acting opioid or opioid combination drug product to provide sustained analgesia along with improvements in sleep quality, compliance, and possibly quality of life. Careful screening of patients being considered for long-term opioid therapy with validated questionnaires can identify patients who may have difficulties in managing opioids. These patients should not be denied access to opioid therapy, but they do require focused monitoring and case management. Ongoing monitoring should focus on the 4 A's (ie, analgesia, activities of daily living, adverse effects, and aberrant drug-related behaviors), and all aspects of patient care must be thoroughly documented.
虽然阿片类药物被视为慢性疼痛管理的主要手段,但由于临床对依赖、滥用和成瘾的担忧以及州和联邦监管机构的法医学担忧,许多初级保健医生对其使用存在争议。对于中度至中度重度疼痛的患者,治疗的选择是长效阿片类药物或阿片类复方制剂,以提供持续镇痛,同时改善睡眠质量、依从性,并可能改善生活质量。使用经过验证的问卷对考虑接受长期阿片类药物治疗的患者进行仔细筛查,可以识别出可能在管理阿片类药物方面有困难的患者。这些患者不应被拒绝接受阿片类药物治疗,但他们确实需要重点监测和病例管理。持续监测应关注4个A(即镇痛、日常生活活动、不良反应和异常药物相关行为),并且必须对患者护理的各个方面进行全面记录。