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用于骨关节炎的浴疗法。

Balneotherapy for osteoarthritis.

作者信息

Verhagen A P, Bierma-Zeinstra S M A, Boers M, Cardoso J R, Lambeck J, de Bie R A, de Vet H C W

机构信息

Erasmus MC University Medical Centre, Dept of General Practice, PO Box 1738, Rotterdam, Netherlands, 3000 DR.

出版信息

Cochrane Database Syst Rev. 2007 Oct 17(4):CD006864. doi: 10.1002/14651858.CD006864.

Abstract

BACKGROUND

Balneotherapy (or spa therapy, mineral baths) for patients with arthritis is one of the oldest forms of therapy. One of the aims of balneotherapy is to soothe the pain and as a consequence to relieve patients' suffering and make them feel well. In this update we included one extra study.

OBJECTIVES

To assess the effectiveness of balneotherapy for patients with osteoarthritis (OA).

SEARCH STRATEGY

We searched the following databases up to October 2006: EMBASE, PubMed, the Cochrane 'Rehabilitation and Related Therapies' Field database, PEDro, CENTRAL (Issue 3, 2006) and performed reference checking and communicated with authors to retrieve eligible studies.

SELECTION CRITERIA

Randomised controlled trials (RCT) comparing balneotherapy with any intervention or no intervention. At least 90% of the patient population had to be diagnosed with OA.

DATA COLLECTION AND ANALYSIS

Two authors independently assessed quality and extracted data. Disagreements were solved by consensus. In the event of clinical heterogeneity or lack of data we refrained from statistical pooling.

MAIN RESULTS

Seven trials (498 patients) were included in this review. Two studies compared spa-treatment with no treatment. One study evaluated baths as an add-on treatment to home exercises and another compared thermal water from Cserkeszölö with tap water (placebo). Three studies evaluated sulphur or Dead Sea baths with no treatment or mineral baths with tap water baths or no treatment. Only one of the trials performed an intention-to-treat analysis and two studies provided data to perform an intention-to-treat analysis ourselves. A 'quality of life' outcome was reported by one trial. We found: silver level evidence concerning the beneficial effects on pain, quality of life and analgesic intake of mineral baths compared to no treatment (SMD between 1.82 and 0.34). a statistically significant difference in pain and function of Dead Sea + sulphur versus no treatment, only at end of treatment (WMD 5.7, 95%CI 3.3 to 8.1), but not at 3 month follow-up (WMD 2.6, 95%CI -1.1 to 6.3). no statistically significant differences in pain or function at one or three months of Dead Sea baths versus no treatment (WMD 0.5, 95%CI -0.6 to 1.6) or at one or three months of sulphur baths versus no treatment (WMD 0.4, 95%CI -0.9 to 1.7). Adverse events were not measured in the included trials.

AUTHORS' CONCLUSIONS: We found silver level evidence (www.cochranemsk.org) concerning the beneficial effects of mineral baths compared to no treatment. Of all other balneological treatments no clear effects were found. However, the scientific evidence is weak because of the poor methodological quality and the absence of an adequate statistical analysis and data presentation. Therefore, the noted "positive findings" should be viewed with caution.

摘要

背景

对关节炎患者进行浴疗法(或温泉疗法、矿泉浴)是最古老的治疗形式之一。浴疗法的目标之一是缓解疼痛,从而减轻患者的痛苦并使其感觉良好。在本次更新中,我们纳入了一项额外的研究。

目的

评估浴疗法对骨关节炎(OA)患者的有效性。

检索策略

截至2006年10月,我们检索了以下数据库:EMBASE、PubMed、Cochrane“康复及相关疗法”领域数据库、PEDro、CENTRAL(2006年第3期),并进行了参考文献核对,还与作者沟通以检索符合条件的研究。

入选标准

比较浴疗法与任何干预措施或不进行干预的随机对照试验(RCT)。至少90%的患者人群必须被诊断为OA。

数据收集与分析

两位作者独立评估质量并提取数据。分歧通过协商解决。若存在临床异质性或数据不足,我们不进行统计合并。

主要结果

本综述纳入了7项试验(498例患者)。两项研究比较了温泉治疗与不治疗。一项研究评估了浴作为家庭锻炼的附加治疗,另一项研究比较了来自Cserkeszölö的温泉水与自来水(安慰剂)。三项研究评估了硫磺浴或死海浴与不治疗、矿泉浴与自来水浴或不治疗的情况。只有一项试验进行了意向性分析,两项研究提供了数据供我们自行进行意向性分析。一项试验报告了“生活质量”结果。我们发现:与不治疗相比,有中等质量证据表明矿泉浴对疼痛、生活质量和镇痛药摄入量有有益影响(标准化均数差在1.82至0.34之间)。死海 + 硫磺浴与不治疗相比,仅在治疗结束时疼痛和功能有统计学显著差异(加权均数差5.7, 95%置信区间3.3至8.1),但在3个月随访时无差异(加权均数差2.6, 95%置信区间 -1.1至6.3)。死海浴与不治疗相比,在1个月或3个月时疼痛或功能无统计学显著差异(加权均数差为0.5, 95%置信区间 -0.6至1.6),硫磺浴与不治疗相比在1个月或3个月时也无差异(加权均数差为0.4, 95%置信区间 -0.9至1.7)。纳入的试验未测量不良事件。

作者结论

我们发现与不治疗相比,有中等质量证据(www.cochranemsk.org)表明矿泉浴有有益影响。对于所有其他浴疗方法,未发现明确效果。然而,由于方法学质量差、缺乏充分的统计分析和数据呈现,科学证据薄弱。因此,应谨慎看待所提及的“阳性结果”。

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