Assessment of acute skin irritation in rabbits using electrical impedance model.

This paper describes the use of an electrical impedance model to assess acute skin reactions to irritant over time. The applied method is noninvasive and quantitative and can detect the irritation before the visual signs. The results showed that the signs of acute irritation (oedema) were present until the second day after irritant application. The method is able to detect the initial phase of irritation and the assessment of regeneration time could be attained by a combination of more than one bioengineering methods.