利用自互信息对阿尔茨海默病患者的脑磁图背景活动进行分析。
Magnetoencephalogram background activity analysis in Alzheimer's disease patients using auto mutual information.
作者信息
Gómez Carlos, Hornero Roberto, Fernández Alberto, Abasolo Daniel, Escudero Javier, López Miguel
机构信息
E. T. S. Ingenieros de Telecomunicación, Valladolid Univ., Valladolid, Spain.
出版信息
Conf Proc IEEE Eng Med Biol Soc. 2006;2006:6181-4. doi: 10.1109/IEMBS.2006.260317.
The goal of this study was to analyze the magnetoencephalogram (MEG) background activity in patients with Alzheimer's disease (AD) using the auto mutual information (AMI). Applied to time series, AMI provides a measure of future points predictability from past points. Five minutes of recording were acquired with a 148-channel whole-head magnetometer (MAGNES 2500 WH, 4D neuroimaging) in 12 patients with probable AD and 12 elderly control subjects. Artifact-free epochs of 20 seconds (3392 points, sample frequency of 169.6 Hz) were selected for our study. Our results showed that the absolute values of the averaged decline rate of AMI were lower in AD patients than in control subjects for all channels. In addition, there were statistically significant differences (p<0.01, Student's t-test) in most channels. These preliminary results suggest that neuronal dysfunction in AD is associated with differences in the dynamical processes underlying the MEG recording.
本研究的目的是使用自互信息（AMI）分析阿尔茨海默病（AD）患者的脑磁图（MEG）背景活动。应用于时间序列时，AMI可衡量根据过去的点预测未来点的能力。使用148通道全头磁强计（MAGNES 2500 WH，4D神经成像）对12例可能患有AD的患者和12名老年对照受试者进行了5分钟的记录。我们的研究选择了20秒（3392个点，采样频率为169.6 Hz）的无伪迹时段。我们的结果表明，所有通道中AD患者的AMI平均下降率绝对值均低于对照受试者。此外，大多数通道存在统计学显著差异（p<0.01，学生t检验）。这些初步结果表明，AD中的神经元功能障碍与MEG记录背后的动态过程差异有关。
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