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电子线与调强光子线联合治疗广泛头皮病变

The treatment of extensive scalp lesions combining electrons with intensity-modulated photons.

作者信息

Chan Maria F, Song Yulin, Burman Chandra, Chui Chen S, Schupak Karen

机构信息

Dept. of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

出版信息

Conf Proc IEEE Eng Med Biol Soc. 2006;2006:152-5. doi: 10.1109/IEMBS.2006.260471.

Abstract

This study was to investigate the feasibility and potential benefits of combining electrons with intensity modulated photons (IMRT+e) for patients with extensive scalp lesions. A case of a patient with an extensive scalp lesion, in which the target volume covered the entire front half of the scalp, is presented. This approach incorporated the electron dose into the inverse treatment planning optimization. The resulting doses to the planning target volume (PTV) and relevant critical structures were compared. Thermoluminescent dosimeters (TLD), diodes, and GAFCHROMIC EBT films were used to verify the accuracy of the techniques. The IMRT+e plan produced a superior dose distribution to the patient as compared to the IMRT plan in terms of reduction of the dose to the brain with the same dose conformity and homogeneity in the target volumes. This study showed that IMRT+e is a viable treatment modality for extensive scalp lesions patients. It provides a feasible alternative to existing treatment techniques, resulting in improved homogeneity of dose to the PTV compared to conventional electron techniques and a decrease in dose to the brain compared to photon IMRT alone.

摘要

本研究旨在探讨将电子线与调强光子束(IMRT+e)联合应用于广泛头皮病变患者的可行性及潜在益处。本文介绍了1例广泛头皮病变患者的病例,其靶区覆盖了头皮的整个前半部分。该方法将电子线剂量纳入逆向治疗计划优化中。比较了所得的计划靶区(PTV)及相关关键结构的剂量。使用热释光剂量计(TLD)、二极管和GAFCHROMIC EBT胶片来验证技术的准确性。与IMRT计划相比,IMRT+e计划在靶区具有相同剂量适形度和均匀性的情况下,降低了对脑的剂量,为患者产生了更优的剂量分布。本研究表明,IMRT+e是广泛头皮病变患者可行的治疗方式。它为现有治疗技术提供了一种可行的替代方案,与传统电子技术相比,PTV剂量的均匀性得到改善,与单纯光子IMRT相比,脑剂量降低。

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