Wu Yin, Tse Hung-Fat, Wu E X
Department of Electrical and Electronic Engineering, University of Hong Kong, Hong Kong SAR, China.
Conf Proc IEEE Eng Med Biol Soc. 2006;2006:1069-72. doi: 10.1109/IEMBS.2006.259840.
Investigation of infarct myocardium structure will lead to better understanding of functional adaptation and remodeling. Diffusion tensor magnetic resonance imaging (DTI) provides a means for rapid and nondestructive characterization of the three-dimensional fiber architecture of myocardium. DTI studies were performed on 10 excised, formalin-fixed hearts of both infarct (two months after left anterior descending coronary artery (LAD) occlusion surgery, n=4) and control (n=6) porcine. Each slice was divided into eight segments, and fractional anisotropy (FA) value and helix angle were measured in multiples short-axis slices, respectively. Infarct myocardium exhibited decreased FA value, flatter helix angle courses fluctuating around small helix angle with greater standard error of the mean (SEM) and smaller range of helix angle. The results provide structure information of infarct myocardium.
对梗死心肌结构的研究将有助于更好地理解功能适应和重塑。扩散张量磁共振成像（DTI）为快速、无损地表征心肌的三维纤维结构提供了一种方法。对10个切除的、用福尔马林固定的猪心脏进行了DTI研究，其中包括梗死心脏（左前降支冠状动脉（LAD）闭塞手术后两个月，n = 4）和对照心脏（n = 6）。将每个切片分为8个节段，分别在多个短轴切片中测量分数各向异性（FA）值和螺旋角。梗死心肌的FA值降低，螺旋角曲线更平缓，围绕小螺旋角波动，平均标准误差（SEM）更大，螺旋角范围更小。这些结果提供了梗死心肌的结构信息。
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