Facchinetti A, Sparacino G, Zanderigo F, Cobelli C
Dept. of Information Engineering, University of Padova, Italy.
Conf Proc IEEE Eng Med Biol Soc. 2006;2006:55-8. doi: 10.1109/IEMBS.2006.259966.
In the recent past, several sensors have been developed which allow continuous glucose monitoring (CGM) for several days. CGM can improve diabetes management and in particular decrease the risk of hypoglycemic events. However, CGM sensors measure glucose concentration in the interstitial fluid (ISF) rather than in plasma and ISF lags plasma glucose. The purpose of this work is to investigate if plasma glucose can be reconstructed from ISF CGM data by using a deconvolution approach, based on the knowledge of the model of plasma-interstitium kinetics. Results obtained in 6 volunteers monitored for 2 days with simultaneous plasma and ISF glucose by the Freestyle Navigator CGM sensor measurements show that calibration is a critical component for a reliable reconstruction of plasma glucose from ISF data.
最近，已经开发出了几种能够进行连续数天血糖监测（CGM）的传感器。CGM可以改善糖尿病管理，特别是降低低血糖事件的风险。然而，CGM传感器测量的是组织间液（ISF）中的葡萄糖浓度，而非血浆中的葡萄糖浓度，并且ISF葡萄糖浓度滞后于血浆葡萄糖浓度。本研究的目的是基于血浆-组织间液动力学模型的知识，研究是否可以通过去卷积方法从ISF CGM数据中重建血浆葡萄糖浓度。通过Freestyle Navigator CGM传感器同时测量6名志愿者的血浆和ISF葡萄糖浓度，持续监测2天，结果表明校准是从ISF数据可靠重建血浆葡萄糖浓度的关键组成部分。
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