在与低游离脂肪酸白蛋白孵育的分离大鼠肝细胞中胰岛素反应性增强。
Increased insulin responsiveness in isolated rat hepatocytes incubated with free fatty acid-poor albumin.
作者信息
Caro J F, Hodges J, Sinha M K
机构信息
Department of Medicine, East Carolina University School of Medicine, Greenville, North Carolina.
出版信息
Horm Metab Res. 1991 Aug;23(8):362-4. doi: 10.1055/s-2007-1003701.
Freshly isolated rat hepatocytes incubated in a medium containing bovine serum albumin partially purified by charcoal treatment at pH 3 are three times more responsive to insulin with regard to alpha-aminoisobutyric acid uptake than those incubated in medium containing regular bovine serum albumin. This finding should facilitate future work in isolated hepatocytes, a cell system that for the most part has been considered relatively unresponsive to insulin.
在含有经pH 3的木炭处理部分纯化的牛血清白蛋白的培养基中孵育的新鲜分离的大鼠肝细胞，在α-氨基异丁酸摄取方面对胰岛素的反应比在含有常规牛血清白蛋白的培养基中孵育的肝细胞高三倍。这一发现应有助于在分离的肝细胞方面开展未来的研究工作，而肝细胞系统在很大程度上一直被认为对胰岛素反应相对不敏感。
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