与炎症性肠病发生相关的遗传因素。
Genetic factors associated with the development of inflammatory bowel disease.
作者信息
Yamamoto-Furusho Jesus-K
机构信息
Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga 15, Col. Seccion XVI, Tlalpan, Mexico, D.F., Mexico.
出版信息
World J Gastroenterol. 2007 Nov 14;13(42):5594-7. doi: 10.3748/wjg.v13.i42.5594.
Abstract
Crohn's disease (CD) and ulcerative colitis (UC) are complex polygenic disorders, characterized by several genes together with environmental factors contributing to the development of inflammatory bowel disease (IBD). Recent advances in research on genetic susceptibility have allowed the identification of diverse genes at different levels: (1) Innate immunity; (2) Antigen presentation molecules; (3) Epithelial integrity; (4) Drug transporter; (5) Cell adhesion. The application of genetic testing into clinical practice is close and all genetic markers may have several clinical implications: prediction of disease phenotype, molecular classification, prevention of complications, and prognosis.
摘要
克罗恩病（CD）和溃疡性结肠炎（UC）是复杂的多基因疾病，其特征是多个基因与环境因素共同导致炎症性肠病（IBD）的发生。遗传易感性研究的最新进展使得在不同水平上鉴定出多种基因：（1）固有免疫；（2）抗原呈递分子；（3）上皮完整性；（4）药物转运体；（5）细胞黏附。基因检测在临床实践中的应用已近在咫尺，所有基因标记可能具有多种临床意义：疾病表型预测、分子分类、并发症预防及预后判断。
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