Watson Lyndsey F, Lumley Judith, Rayner Jo-Anne, Potter Anne
Mother and Child Health Research, La Trobe University, 324-328 Little Lonsdale Street, Melbourne, Victoria 3000, Australia.
Midwifery. 2008 Dec;24(4):509-20. doi: 10.1016/j.midw.2007.07.004. Epub 2007 Oct 22.
to present issues associated with recruitment of women in maternity hospitals to a population-based case-control study of very preterm birth.
a descriptive study of the recruitment process.
all maternity hospitals, including three providing neonatal intensive care services, in Victoria, Australia from April 2002 to April 2004.
cases were women who had a singleton birth between 20 and 31+6 weeks of gestation. Controls were a random selection of women having a singleton birth of at least 37 completed weeks of gestation in the same time period as the cases.
ethical approval was obtained from 73 of 77 maternity hospitals. Hospitals considered that privacy laws required that women should be approached initially by hospital staff for recruitment into the research study. Extensive effort was put into liaising with hospital personnel, determining hospital-specific protocols for approaching women and developing relationships with doctors, midwives and ward clerks. Recurrent reminders were provided to all hospitals. Of the 2785 women (cases and controls) ascertained as eligible, 13% of cases with surviving babies, 11% of controls and 74% of cases whose babies did not survive were not approached to participate in the study. Within these groups, there was variation by gestation and hospital. Once women were approached, 72% were interviewed. The interview response proportion was 50%.
recruitment to studies in the maternity setting in the postpartum period is a challenge. Barriers to recruitment that may have introduced selection bias in this study include: recruitment at many hospitals; short postnatal hospital stay; reliance on hospital staff to make the first approach to women; and low response from women whose babies did not survive. A dialogue between researchers and clinical midwives is proposed to explore ways of increasing researchers' understanding of the complex and demanding hospital environment, and to improve research awareness among clinical midwives.
介绍在产科医院招募女性参与基于人群的极早产病例对照研究相关的问题。
对招募过程的描述性研究。
2002年4月至2004年4月期间澳大利亚维多利亚州的所有产科医院，包括三家提供新生儿重症监护服务的医院。
病例为妊娠20至31 + 6周之间单胎分娩的女性。对照是在与病例相同时间段内随机选取的妊娠至少37足周单胎分娩的女性。
77家产科医院中的73家获得了伦理批准。医院认为隐私法要求应由医院工作人员首先接触女性以招募其参与研究。在与医院工作人员联络、确定针对女性的医院特定方案以及与医生、助产士和病房办事员建立关系方面投入了大量精力。向所有医院反复发送提醒。在确定符合条件的2785名女性（病例和对照）中，存活婴儿的病例中有13%、对照中有11%以及婴儿未存活的病例中有74%未被邀请参与研究。在这些组中，存在孕周和医院方面的差异。一旦接触女性，72%的女性接受了访谈。访谈应答比例为50%。
产后在产科环境中进行研究的招募是一项挑战。本研究中可能引入选择偏倚的招募障碍包括：许多医院进行招募；产后住院时间短；依赖医院工作人员首先接触女性；以及婴儿未存活的女性应答率低。建议研究人员与临床助产士进行对话，以探索增加研究人员对复杂且要求高的医院环境的理解的方法，并提高临床助产士的研究意识。
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