Feringa Harm H H, Karagiannis Stefanos, Vidakovic Radosav, Noordzij Peter G, Brugts Jasper J, Schouten Olaf, van Sambeek Marc R H M, Bax Jeroen J, Poldermans Don
Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Am J Cardiol. 2007 Nov 1;100(9):1479-84. doi: 10.1016/j.amjcard.2007.06.043. Epub 2007 Aug 27.
This study examines differences in cardiac arrhythmias, perioperative myocardial ischemia, troponin T release, and cardiovascular events between endovascular and open repair of abdominal aortic aneurysms (AAAs). Of 175 patients, 126 underwent open AAA repair and 49 underwent endovascular AAA repair. Continuous 12-lead electrocardiographic monitoring, starting 1 day before surgery and continuing through 2 days after surgery, was used for cardiac arrhythmia and myocardial ischemia detection. Troponin T was measured on postoperative days 1, 3, and 7 and before discharge. Cardiac events (cardiac death or Q-wave myocardial infarction) were noted at 30 days and at follow-up (mean 2.3 years). New-onset atrial fibrillation, nonsustained ventricular tachycardia, sustained ventricular tachycardia, and ventricular fibrillation occurred in 5%, 17%, 2%, and 1% of patients, respectively. Myocardial ischemia, troponin T release, and 30-day and long-term cardiac events occurred in 34%, 29%, 6%, and 10% of patients, respectively. Significantly higher heart rates and less heart rate variability were observed in the open AAA repair group. Cardiac arrhythmias were less prevalent in the endovascular AAA repair group (14% vs 29%, p = 0.04). Endovascular repair was also significantly associated with less myocardial ischemia (odds ratio 0.14, 95% confidence interval 0.05 to 0.40, p <0.001) and troponin T release (odds ratio 0.10, 95% confidence interval 0.02 to 0.32, p <0.001) and lower 30-day mortality (zero vs 8.7%, p = 0.03) and 30-day cardiac event rates (zero vs 7.9%, p = 0.04). Long-term mortality and cardiac event rates were not significantly lower in the endovascular AAA repair group. In conclusion, endovascular AAA repair is associated with a lower incidence of perioperative cardiac arrhythmias, myocardial ischemia, troponin T release, cardiac events, and all-cause mortality compared with open AAA repair.
本研究探讨腹主动脉瘤(AAA)血管内修复与开放修复在心律失常、围手术期心肌缺血、肌钙蛋白T释放及心血管事件方面的差异。175例患者中,126例行AAA开放修复,49例行AAA血管内修复。采用连续12导联心电图监测,从手术前1天开始,持续至术后2天,以检测心律失常和心肌缺血。在术后第1天、第3天、第7天及出院前测定肌钙蛋白T。记录30天及随访时(平均2.3年)的心脏事件(心源性死亡或Q波心肌梗死)。新发房颤、非持续性室性心动过速、持续性室性心动过速及室颤的发生率分别为5%、17%、2%和1%。心肌缺血、肌钙蛋白T释放、30天及长期心脏事件的发生率分别为34%、29%、6%和10%。AAA开放修复组观察到心率显著更高且心率变异性更低。AAA血管内修复组心律失常的发生率更低(14%对29%,p = 0.04)。血管内修复还与较少的心肌缺血(比值比0.14,95%置信区间0.05至0.40,p <0.001)、肌钙蛋白T释放(比值比0.10,95%置信区间0.02至0.32,p <0.001)、更低的30天死亡率(0对8.7%,p = 0.03)及30天心脏事件发生率(0对7.9%,p = 0.04)显著相关。AAA血管内修复组的长期死亡率和心脏事件发生率并未显著更低。总之,与AAA开放修复相比,AAA血管内修复与围手术期心律失常、心肌缺血、肌钙蛋白T释放、心脏事件及全因死亡率的发生率更低相关。