二维、三维高剂量和三维低剂量门控心肌82Rb正电子发射断层显像的比较

Comparison of 2D, 3D high dose and 3D low dose gated myocardial 82Rb PET imaging.

作者信息

Knešaurek Karin, Machac Josef, Ho Kim Jong

机构信息

Division of Nuclear Medicine, The Mount Sinai Medical Centre, New York, USA.

出版信息

BMC Nucl Med. 2007 Oct 22;7:4. doi: 10.1186/1471-2385-7-4.

DOI:10.1186/1471-2385-7-4

PMID:17953754

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2140263/

Abstract

BACKGROUND

We compared 2D, 3D high dose (HD) and 3D low dose (LD) gated myocardial Rb-82 PET imaging in 16 normal human studies. The main goal in the paper is to evaluate whether the images obtained by a 3D LD studies are still of comparable clinical quality to the images obtained with the 2D HD or 3D HD studies.

METHODS

All 2D and 3D HD studies were performed with 2220 MBq of Rb-82. The 3D LD were performed with 740 MBq of Rb-82. A GE Advance PET system was used for acquisition. Polar maps were created and used to calculate noise among (NAS) and within (NWS) the segments in the noise analysis. In addition, the contrast between left ventricular (LV) wall and LV cavity was also analysed. For 13 subjects, ejection fraction (EF) on 2D and 3D studies was calculated using QGS program.

RESULTS

For the H20 reconstruction filter, the mean contrast in mid-ventricular short-axis slice was 0.33 +/- 0.06 for 2D studies. The same contrast for the 3D HD studies was 0.38 +/- 0.07 and for 3D LD, it was 0.34 +/- 0.08. For the 6 volunteers where 3D HD was used, NAS was 3.6410-4 and NWS was 1.7910-2 for 2D studies, and NAS was 3.7010-4 and NWS was 1.8510-2 for 3D HD studies, respectively. For the other 10 volunteers where 3D LD was used, NAS was 3.8510-4 and NWS was 1.8210-2 for the 2D studies, and NAS was 5.5810-4 and NWS was 1.9110-2 for the 3D LD studies, respectively. For the sharper H13 filter, the data followed the same pattern, with slightly higher values of contrast and noise. EF values in 2D and 3D were close. The Pearson's correlation coefficient was 0.90. The average difference from 13 subjects was 8.3%.

CONCLUSION

2D and 3D HD gating Rb-82 PET cardiac studies have similar contrast, ejection fractions and noise levels. 3D LD gating imaging, gave comparable results in terms of contrast, EF and noise to either 2D or 3D HD gating PET imaging. 3D LD PET gated imaging can make Rb-82 PET cardiac imaging more affordable with significantly less radiation exposure to the patients.

摘要

背景

我们在16项正常人体研究中比较了二维、三维高剂量（HD）和三维低剂量（LD）门控心肌Rb-82正电子发射断层显像（PET）成像。本文的主要目的是评估三维LD研究获得的图像在临床质量上是否仍与二维HD或三维HD研究获得的图像相当。

方法

所有二维和三维HD研究均使用2220MBq的Rb-82进行。三维LD研究使用740MBq的Rb-82进行。采用GE Advance PET系统进行采集。创建极坐标图并用于在噪声分析中计算节段间（NAS）和节段内（NWS）的噪声。此外，还分析了左心室（LV）壁与LV腔之间的对比度。对于13名受试者，使用QGS程序计算二维和三维研究中的射血分数（EF）。

结果

对于H20重建滤波器，二维研究中左心室短轴切片的平均对比度为0.33±0.06。三维HD研究的相同对比度为0.38±0.07，三维LD研究的相同对比度为0.34±0.08。对于使用三维HD的6名志愿者，二维研究中NAS为3.64×10-4，NWS为1.79×10-2，三维HD研究中NAS为3.70×10-4，NWS为1.85×10-2。对于使用三维LD的其他10名志愿者，二维研究中NAS为3.85×10-4，NWS为1.82×10-2，三维LD研究中NAS为5.58×10-4，NWS为1.91×10-2。对于更锐利的H13滤波器，数据遵循相同模式，对比度和噪声值略高。二维和三维中的EF值接近。皮尔逊相关系数为0.90。13名受试者的平均差异为8.3%。