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转铁蛋白在动脉粥样硬化中的作用。

The role of transferrin in atherosclerosis.

作者信息

Kibel Aleksandar, Belovari Tatjana, Drenjancević-Perić Ines

机构信息

Department of Physiology and Immunology, School of Medicine, University Josip Juraj Strossmayer in Osijek, J. Huttlera 4, 31 000 Osijek, Croatia.

出版信息

Med Hypotheses. 2008;70(4):793-7. doi: 10.1016/j.mehy.2007.07.039. Epub 2007 Oct 23.

Abstract

Transferrin is a plasma protein with the primary role of transporting iron through the body and delivering it to the cells that utilize it. Because free ionic iron is very toxic by creating free radicals, the importance of transferrin lies in its antioxidant properties. Atherosclerosis, a pathological process affecting arterial walls, is a chronic inflammatory response in which oxidative stress caused by free radicals is a key factor in its pathogenesis. We postulate therefore that the plasma protein transferrin acts protectively in these events, by holding iron in containment and reducing oxidative stress. Furthermore, it is possible that a disturbance in transferrin function and homeostasis is a direct factor triggering and exacerbating atherosclerosis. Decreased transferrin levels, increased transferrin saturation, defective transferrin binding of iron, or other disorders may lead to increased oxidative stress and lipid peroxidation involved in the pathology of atherosclerosis. Some oxidative stress-related diseases have been linked to such systemic transferrin abnormalities, and we hypothesize that similar disruptions could account for an unfavorable microenviroment in the evolvement of atherosclerotic plaques. If confirmed, this proposed mechanism would significantly improve our understanding of the disease.

摘要

转铁蛋白是一种血浆蛋白,其主要作用是在体内运输铁并将其输送到利用铁的细胞中。由于游离离子铁通过产生自由基具有很强的毒性,转铁蛋白的重要性在于其抗氧化特性。动脉粥样硬化是一种影响动脉壁的病理过程,是一种慢性炎症反应,其中自由基引起的氧化应激是其发病机制的关键因素。因此,我们推测血浆蛋白转铁蛋白在这些事件中发挥保护作用,通过抑制铁并减少氧化应激。此外,转铁蛋白功能和内环境稳态的紊乱可能是触发和加剧动脉粥样硬化的直接因素。转铁蛋白水平降低、转铁蛋白饱和度增加、转铁蛋白与铁的结合缺陷或其他紊乱可能导致参与动脉粥样硬化病理过程的氧化应激和脂质过氧化增加。一些与氧化应激相关的疾病与这种全身性转铁蛋白异常有关,我们推测类似的破坏可能是动脉粥样硬化斑块演变中不利微环境的原因。如果得到证实,这一提出的机制将显著提高我们对该疾病的理解。

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