连续腰丛阻滞与全身使用阿片类药物相比,在髋关节置换术后可提供更好的镇痛效果且副作用更少:一项随机对照试验。

Continuous lumbar plexus block provides improved analgesia with fewer side effects compared with systemic opioids after hip arthroplasty: a randomized controlled trial.

作者信息

Siddiqui Zafar I, Cepeda M Soledad, Denman William, Schumann Roman, Carr Daniel B

机构信息

Department of Anesthesia, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA.

出版信息

Reg Anesth Pain Med. 2007 Sep-Oct;32(5):393-8. doi: 10.1016/j.rapm.2007.04.008.

Abstract

BACKGROUND AND OBJECTIVES

A single injection lumbar plexus block for acute pain management after hip surgery is usually limited to the immediate postoperative period. We conducted a randomized controlled trial to determine the effect of a continuous lumbar plexus block on perioperative opioid requirements and pain intensity.

METHODS

Adult patients undergoing elective hip arthroplasty under general anesthesia were randomized to continuous lumbar plexus block combined with patient-controlled analgesia (PCA) or PCA only for postoperative pain. Patients allocated to the lumbar plexus block had the catheter placed before surgery. Patients were followed for 36 hours. Perioperative opioid requirement was the primary outcome; secondary outcomes included assessment of pain intensity, patient and surgeon satisfaction with the analgesic technique, and occurrence of nausea and vomiting.

RESULTS

Seventeen patients were randomized to each treatment group. Compared with patients in the PCA group, patients in the continuous lumbar plexus block group required less morphine (12 mg) (95% CI, -12.9 to -3.9), had on average less pain (-2.1 units on a 0 to 10 scale) (95% CI, -3.8 to -1.1), were more satisfied with their analgesic technique, and experienced less nausea and vomiting. One patient in the continuous lumbar plexus block developed a delayed paresis and 1 patient in the PCA group developed respiratory depression.

CONCLUSIONS

Continuous lumbar plexus block combined with PCA is superior to PCA alone for postoperative pain management following hip replacement. It reduces opioid requirements, opioid related side effects, and enhances patient satisfaction. However, additional research is required to determine its safety in light of the neurologic injury observed.

摘要

背景与目的

单次注射腰丛神经阻滞用于髋关节手术后急性疼痛管理通常仅限于术后即刻阶段。我们进行了一项随机对照试验,以确定连续腰丛神经阻滞对围手术期阿片类药物需求及疼痛强度的影响。

方法

接受全身麻醉下择期髋关节置换术的成年患者被随机分为连续腰丛神经阻滞联合患者自控镇痛(PCA)组或仅采用PCA进行术后镇痛组。分配至腰丛神经阻滞组的患者在手术前放置导管。对患者进行36小时随访。围手术期阿片类药物需求是主要结局;次要结局包括疼痛强度评估、患者及外科医生对镇痛技术的满意度以及恶心和呕吐的发生率。

结果

每个治疗组均有17例患者被随机分组。与PCA组患者相比,连续腰丛神经阻滞组患者所需吗啡量更少(12毫克)(95%可信区间,-12.9至-3.9),平均疼痛程度更低(0至10分制中低2.1分)(95%可信区间,-3.8至-1.1),对镇痛技术更满意,且恶心和呕吐发生率更低。连续腰丛神经阻滞组有1例患者出现延迟性轻瘫,PCA组有1例患者出现呼吸抑制。

结论

连续腰丛神经阻滞联合PCA在髋关节置换术后疼痛管理方面优于单纯PCA。它可减少阿片类药物需求、与阿片类药物相关的副作用,并提高患者满意度。然而,鉴于观察到的神经损伤情况,需要进一步研究以确定其安全性。

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