儿茶酚-O-甲基转移酶（COMT）基因val158met多态性与瑞典男性的骨折患病率相关。

The COMT val158met polymorphism is associated with prevalent fractures in Swedish men.

作者信息

Eriksson Anna L, Mellström Dan, Lorentzon Mattias, Orwoll Eric S, Redlund-Johnell Inga, Grundberg Elin, Holmberg Anna, Ljunggren Osten, Karlsson Magnus K, Ohlsson Claes

机构信息

Center for Bone Research at the Sahlgrenska Academy, Departments of Internal Medicine and Geriatrics, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.

出版信息

Bone. 2008 Jan;42(1):107-12. doi: 10.1016/j.bone.2007.08.045. Epub 2007 Sep 18.

DOI:10.1016/j.bone.2007.08.045

PMID:17962094

Abstract

INTRODUCTION

Sex steroids are important for growth and maintenance of the skeleton. Catechol-O-methyltransferase (COMT) is an estrogen degrading enzyme. The COMT val158met polymorphism results in a 60-75% difference in enzyme activity between the val (high activity=H) and met (low activity=L) variants. We have previously reported that this polymorphism is associated with bone mineral density (BMD) in young men. The aim of this study was to investigate associations between COMT val158met, BMD and fractures in elderly men.

METHODS

Population-based study of Swedish men 75.4, SD 3.2, years of age. Fractures were reported using standardized questionnaires. Fracture and genotype data were available from 2,822 individuals.

RESULTS

Total number of individuals with self-reported fracture was 989 (35.0%). Prevalence of >or=1 fracture was 37.2% in COMT(LL), 35.7% in COMT(HL) and 30.4% in COMT(HH) (p<0.05). Early fractures (<or=50 years of age) were less common in COMT(HH) than in the combined COMT(LL+HL) genotype, OR 0.78 (95% CI 0.63-0.97). No associations were found for late fractures (>50 years of age). The OR for fracture of the non-weight bearing skeleton in COMT(HH) compared with COMT(LL+HL) was 0.74 (95% CI 0.59-0.92). No associations between COMT val158met and BMD were found in this cohort of elderly men.

CONCLUSIONS

The COMT val158met polymorphism is associated with life time fracture prevalence in elderly Swedish men. This association is mainly driven by early fractures (<or=50 years of age).

摘要

引言

性类固醇对骨骼的生长和维持很重要。儿茶酚-O-甲基转移酶（COMT）是一种雌激素降解酶。COMT val158met多态性导致val（高活性=H）和met（低活性=L）变体之间的酶活性存在60-75%的差异。我们之前曾报道，这种多态性与年轻男性的骨密度（BMD）有关。本研究的目的是调查老年男性中COMT val158met、骨密度和骨折之间的关联。

方法

对瑞典75.4岁（标准差3.2岁）男性进行基于人群的研究。使用标准化问卷报告骨折情况。2822名个体有骨折和基因型数据。

结果

自我报告骨折的个体总数为989人（35.0%）。COMT（LL）中≥1次骨折的患病率为37.2%，COMT（HL）中为35.7%，COMT（HH）中为30.4%（p<0.05）。COMT（HH）中早期骨折（≤50岁）比COMT（LL+HL）联合基因型少见，比值比为0.78（95%可信区间0.63-0.97）。未发现与晚期骨折（>50岁）有关联。与COMT（LL+HL）相比，COMT（HH）中非负重骨骼骨折的比值比为0.74（95%可信区间0.59-0.92）。在该老年男性队列中未发现COMT val158met与骨密度之间有关联。