Synthesis and analgesic activity evaluation of some agmatine derivatives.
作者信息
He Hongxia, Liu Mengjia, Zheng Zhibing, Liu Ying, Xiao Junhai, Su Ruibin, Hu Chun, Li Jin, Li Song
机构信息
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China.
出版信息
Molecules. 2006 Jun 12;11(6):393-402. doi: 10.3390/11060393.
Abstract
A series of N,N'-disubstituted-2-nitroethene-1,1-diamine and N,N'-disubstituted- N''-cyanoguanidine derivatives were prepared and evaluated for in vivo analgesic activity. The blood brain barrier (BBB) VolSurf model was used to predict the BBB permeation profiles of our synthesized compounds. Some compounds show both remarkable analgesic activity and good BBB permeation profiles, and these compounds might be developed for treatment of opioid tolerance and dependence.
摘要
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