二烯二酸酯的区域选择性串联二甲基硫鎓叶立德加成-消除烯化反应：合成1,3-丁二烯-2-基丙二酸酯的新途径。

Regioselective tandem dimethylsulfonium methylide addition-eliminative olefination of diendioates: a novel route to 1,3-butadien-2-ylmalonates.

作者信息

Singh Rekha, Ghosh Sunil K

机构信息

Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai 400 085, India.

出版信息

Org Lett. 2007 Nov 22;9(24):5071-4. doi: 10.1021/ol702384s. Epub 2007 Oct 27.

DOI:10.1021/ol702384s

PMID:17963400

Abstract

The appropriate choice of dimethylsulfonium methylide generation conditions enables the highly regioselective tandem ylide addition-eliminative olefination to 1,3-dienedioates providing 1,3-butadien-2-ylmalonates, a novel class of 2-substituted 1,3-dienes suitable for quick assembly of precursors for type 2 intramolecular Diels-Alder reactions.

摘要

二甲基硫叶立德生成条件的恰当选择，能够实现对1,3 - 二烯二酸酯进行高度区域选择性的串联叶立德加成 - 消除烯化反应，生成1,3 - 丁二烯 - 2 - 基丙二酸酯，这是一类新型的2 - 取代1,3 - 二烯，适用于快速组装2型分子内狄尔斯 - 阿尔德反应的前体。

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二烯二酸酯的区域选择性串联二甲基硫鎓叶立德加成-消除烯化反应：合成1,3-丁二烯-2-基丙二酸酯的新途径。

Regioselective tandem dimethylsulfonium methylide addition-eliminative olefination of diendioates: a novel route to 1,3-butadien-2-ylmalonates.

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二烯二酸酯的区域选择性串联二甲基硫鎓叶立德加成-消除烯化反应：合成1,3-丁二烯-2-基丙二酸酯的新途径。

Regioselective tandem dimethylsulfonium methylide addition-eliminative olefination of diendioates: a novel route to 1,3-butadien-2-ylmalonates.

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