心肌梗死患者血清干扰素-γ诱导蛋白10水平升高，且与梗死面积呈负相关。
Serum interferon-gamma-inducible protein 10 level was increased in myocardial infarction patients, and negatively correlated with infarct size.
作者信息
Koten Kazuya, Hirohata Satoshi, Miyoshi Toru, Ogawa Hiroko, Usui Shinichi, Shinohata Ryoko, Iwamoto Mutsumi, Kitawaki Tomoki, Kusachi Shozo, Sakaguchi Kosaku, Ohe Tohru
机构信息
Department of Medicine and Medical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
出版信息
Clin Biochem. 2008 Jan;41(1-2):30-7. doi: 10.1016/j.clinbiochem.2007.10.001. Epub 2007 Oct 11.
OBJECTIVES
We examined the serum levels of interferon-gamma-inducible protein 10 (IP-10), an inflammation-induced chemokine, in acute myocardial infarction (AMI).
DESIGN AND METHODS
The subjects were 33 AMI patients, 20 stable angina pectoris patients (AP) and 20 normal subjects. In AMI patients, blood samples were collected before percutaneous coronary intervention (PCI) and on days 3, 7 and 28.
RESULTS
Patients with AMI showed significantly higher serum IP-10 levels (137.5+/-79.8 pg/mL) than control subjects (91.2+/-40.1 pg/mL) and patients with AP (93.3+/-41.1 pg/mL). The serum IP-10 level before PCI was negatively correlated with infarct size, as indicated by cumulative release of creatine kinase (CK) and peak CK and its isoenzyme CK-MB. Stepwise multiple regression analysis revealed that the serum IP-10 level before PCI was an independent predictor of cumulative CK release.
CONCLUSIONS
The serum IP-10 level was increased in AMI, and a higher level of serum IP-10 before PCI may be informative regarding infarct size.
目的
我们检测了急性心肌梗死（AMI）患者血清中炎症诱导趋化因子γ干扰素诱导蛋白10（IP - 10）的水平。
设计与方法
研究对象包括33例AMI患者、20例稳定型心绞痛（AP）患者和20例正常受试者。对于AMI患者，在经皮冠状动脉介入治疗（PCI）前以及第3、7和28天采集血样。
结果
AMI患者血清IP - 10水平（137.5±79.8 pg/mL）显著高于对照组（91.2±40.1 pg/mL）和AP患者（93.3±41.1 pg/mL）。PCI前血清IP - 10水平与梗死面积呈负相关，这由肌酸激酶（CK）的累积释放、CK峰值及其同工酶CK - MB所表明。逐步多元回归分析显示，PCI前血清IP - 10水平是CK累积释放的独立预测因子。
结论
AMI患者血清IP - 10水平升高，PCI前较高的血清IP - 10水平可能有助于了解梗死面积。
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