对于重度抑郁症，失调结合蛋白基因（DTNBP1）的3种多态性是否存在保护性单倍型？
Is there protective haplotype of dysbindin gene (DTNBP1) 3 polymorphisms for major depressive disorder.
作者信息
Kim Jung-Jin, Mandelli Laura, Pae Chi-Un, De Ronchi Diana, Jun Tae-Youn, Lee Chul, Paik In-Ho, Patkar Ashwin A, Steffens David, Serretti Alessandro, Han Changsu
机构信息
Department of Psychiatry, The Catholic University of Korea College of Medicine, 505 Banpo-Dong, Seocho-Gu, Seoul 137-701, South Korea.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):375-9. doi: 10.1016/j.pnpbp.2007.09.002. Epub 2007 Sep 11.
Dysbindin gene has been repeatedly associated with psychiatric disorders and schizophrenia in particular. This study aimed to investigate the variants of dysbindin gene in major depressive disorder (MDD). One hundred and eighty eight patients with MDD and 350 controls were investigated for 4 variants within the dysbindin gene (rs3213207 A/G, rs1011313 C/T, rs760761 C/T, and rs2619522 A/C). Haplotype analyses revealed a significant association with MDD (p=0.0007, protective A-C-T-A and A-C-C-C haplotypes), in particular the effect was due to the rs760761 (C/T) and rs2619522 (A/C) haplotype (p=0.000026). These results suggest a protective effect of some dysbindin gene haplotypes on the development of MDD. Coupled with previous findings on schizophrenia, our finding suggests that dysbindin gene variants may have a role in the susceptibility to MDD. Adequately powered further studies in different ethnic groups are warranted.
失调结合蛋白基因一直与精神疾病，尤其是精神分裂症反复相关。本研究旨在调查重度抑郁症（MDD）中失调结合蛋白基因的变异情况。对188例MDD患者和350名对照者进行了失调结合蛋白基因内4种变异（rs3213207 A/G、rs1011313 C/T、rs760761 C/T和rs2619522 A/C）的研究。单倍型分析显示与MDD存在显著关联（p = 0.0007，保护性单倍型A-C-T-A和A-C-C-C），特别是该效应归因于rs760761（C/T）和rs2619522（A/C）单倍型（p = 0.000026）。这些结果表明某些失调结合蛋白基因单倍型对MDD的发生具有保护作用。结合先前关于精神分裂症的研究结果，我们的发现表明失调结合蛋白基因变异可能在MDD易感性中起作用。有必要在不同种族群体中开展有足够样本量的进一步研究。
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