Zarski Jean-Pierre, Bedossa Pierre, Bronowicki Jean-Pierre, Doffoel Michel, Poynard Thierry
Clinique Universitaire d'Hépato-Gastroentérologie, Pôle DIGI-DUNE, Unité INSERM U 548, CHU de Grenoble, Grenoble cedex 9.
Gastroenterol Clin Biol. 2007 Aug-Sep;31(8-9 Pt 3):4S34-9.
Non invasive fibrosis markers, recently developed, are now an interesting alternative to liver biopsy in order to appreciate the severity of chronic hepatitis C. Serological markers, especially Fibrotest and Fibrometer, have a good diagnostic accuracy to discriminate patients with mild fibrosis to those with severe fibrosis. For intermediate stages, the discordance is very important and often justifies liver biopsy or using of several markers. Transient elastography (Fibroscan) is a new non invasive method subject to good conditions of utilisation. Diagnostic accuracy is improved by the using of all the markers, especially of Fibrotest. Transient elastography is also a promising method for assessing the severity of cirrhosis.
最近开发的非侵入性纤维化标志物，现在是肝活检的一种有趣替代方法，用于评估慢性丙型肝炎的严重程度。血清学标志物，尤其是Fibrotest和Fibrometer，在区分轻度纤维化患者和重度纤维化患者方面具有良好的诊断准确性。对于中间阶段，不一致性非常重要，通常需要进行肝活检或使用多种标志物。瞬时弹性成像（Fibroscan）是一种新的非侵入性方法，使用条件良好。通过使用所有标志物，尤其是Fibrotest，诊断准确性得到提高。瞬时弹性成像也是评估肝硬化严重程度的一种有前景的方法。
